Second, it can also improve the sensitivity of tumor detection by enabling either high resolution ultrasound imaging, e.g. First, it might allow localized cancer treatment at tumor site by enabling therapeutic nano-systems to specifically target tumors via passive, magnetic, or active targeting. Indeed, it gathers a series of advantages. Among the different types of nanotechnologies that could be considered for such purpose, the combination of nano-systems with ultrasounds is especially appealing. by making cancer treatments less expensive and thus accessible for people living in countries without social security, by making certain heavy operations such as general anesthesia unnecessary, or by improving the benefit to risk ratio of cancer treatments. While nanotechnology often appears as an all-encompassing and abstract term, it may in fact have the potential to significantly lower this rate, e.g. These trends tend to be particularly pronounced in the least medicalized countries and for advanced or difficult to treat cancers. Graphical AbstractĬancer mortality rate increases with population aging or exposure to risk factors such as alcohol, tobacco consumption, obesity, or the presence of a pandemic like COVID-19, which limits access to patient care. This review highlights the clinical potential of these combined treatments that can improve the benefit/risk ratio of current cancer treatments. Interestingly, the way in which nano-systems act against a tumor could in principle also be adjusted by accurately selecting the nano-system among a large choice and by tuning the values of the ultrasound parameters, which can lead, due to their mechanical nature, to specific effects such as cavitation that are usually not observed with purely electromagnetic waves and can potentially help destroying the tumor. Such dual size is advantageous since it enables gathering within the same unit the targeting properties of nano bubbles via EPR effect and the enhanced ultrasound contrasting properties of micro bubbles.
Furthermore, some nano-systems display adjustable sizes, i.e. The efficacy of these methods can be further improved by combining them with various nano-systems, thus enabling: (i) a better resolution of ultrasound imaging, allowing for example the visualization of angiogenic blood vessels, (ii) the specific tumor targeting of anti-tumor chemotherapeutic drugs or gases attached to or encapsulated in nano-systems and released in a controlled manner in the tumor under ultrasound application, (iii) tumor treatment at tumor site using more moderate heating temperatures than with HIFU.
to collect tumor tissues in the right location using ultrasound-guided biopsy, to image the region of the tumor using more affordable and easier to use apparatus than MRI and CT, or to ablate tumor tissues using HIFU. Ultrasounds are often used in cancer treatment protocols, e.g.
0 kommentar(er)
